Flex-nucleoside analogues – Novel therapeutics against filoviruses. Issue 12 (15th June 2017)

• Record Type: Journal Article
• Authors: Yates, Mary K.; Raje, Mithun R.; Chatterjee, Payel; Spiropoulou, Christina F.; Bavari, Sina; Flint, Mike; Soloveva, Veronica; Seley-Radtke, Katherine L.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 12(2017)
• Page Start: 2800
• Page End: 2802
• Publication Date: 2017-06-15
• Subjects: Nucleoside -- Filovirus -- Ebola -- Antiviral -- Fleximers; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.04.069
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC50 = 2 μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC50 of 7 μM.