Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments. Issue 11 (1st June 2017)

• Record Type: Journal Article
• Authors: Wang, Siyao; Corcilius, Leo; Sharp, Phillip P.; Payne, Richard J.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 25:Issue 11(2017)
• Page Start: 2895
• Page End: 2900
• Publication Date: 2017-06-01
• Subjects: Glycopeptides -- Glycosylation -- GlcNAcylation -- Arginine -- SPPS -- TRADD -- FADD; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2017.03.012
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Herein we describe the synthesis of glycopeptide fragments from the death domains of TRADD and FADD bearing the recently discovered Nω -GlcNAc-β-arginine post-translational modification. TRADD and FADD glycopeptides were accessed through the use of a suitably protected synthetic glycosylamino acid 'cassette' that could be directly incorporated into conventional solid phase peptide synthesis (SPPS) protocols.