Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection. Issue 4 (August 2015)

• Record Type: Journal Article
• Authors: Bogoch, Isaac I.; Wilson, Michael R.; Chad, David A.; Venna, Nagagopal
• Is Part Of: Neurology. Volume 2:Issue 4(2015)
• Publication Date: 2015-08
• Subjects: Neuroimmunology -- Periodicals; Neurology -- Periodicals; 616.8
• DOI: 10.1212/NXI.0000000000000113
• Languages: English
• ISSNs: 2332-7812

Abstract

Abstract : Objective: To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. Methods: A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases. Results: Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy. Conclusions: This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV.