Photothermal triggered protein release from an injectable polycaprolactone-based microspherical depot. Issue 20 (16th May 2017)

• Record Type: Journal Article
• Authors: Ge, Chunling; Basuki, Johan S.; White, Jacinta; Hou, Ruixia; Peng, Yong; Hughes, Timothy C.; Tan, Tianwei
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 20(2017)
• Page Start: 3634
• Page End: 3639
• Publication Date: 2017-05-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00837f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Visible light mediated controlled release of biologically active enzymes was confirmed by released horseradish peroxidase's ability to ameliorate H2 O2 cytotoxicity in vitro . Abstract : Upon exposure to visible light, controlled multiple dose protein release was demonstrated by using a microspherical depot composed of biodegradable poly(ε-caprolactone) (PCL), bovine serum albumin (BSA) or horseradish peroxidase (HRP) as model protein, polymer-coated gold nanoparticles as photothermal component, which can potentially reduce the number of invasive therapeutic injections.