Defining the immunogenicity and antigenicity of HLA epitopes is crucial for optimal epitope matching in clinical renal transplantation. (5th April 2017)

• Record Type: Journal Article
• Authors: Kramer, C. S. M.; Roelen, D. L.; Heidt, S.; Claas, F. H. J.
• Is Part Of: HLA. Volume 90:Number 1(2017)
• Page Start: 5
• Page End: 16
• Publication Date: 2017-04-05
• Subjects: antibody -- antigenicity -- HLA epitope -- immunogenicity -- transplantation; Immunogenetics -- Periodicals; Antigens -- Periodicals; HLA histocompatibility antigens -- Periodicals; 571.9645
• DOI: 10.1111/tan.13038
• Languages: English
• ISSNs: 2059-2302

Abstract

Abstract : Transplantation of an human leukocyte antigen (HLA) mismatched graft can lead to the development of donor‐specific antibodies (DSA), which can result in antibody mediated rejection and graft loss as well as complicate repeat transplantation. These DSA are induced by foreign epitopes present on the mismatched HLA antigens of the donor. However, not all epitopes appear to be equally effective in their ability to induce DSA. Understanding the characteristics of HLA epitopes is crucial for optimal epitope matching in clinical transplantation. In this review, the latest insights on HLA epitopes are described with a special focus on the definition of immunogenicity and antigenicity of HLA epitopes. Furthermore, the use of this knowledge to prevent HLA antibody formation and to select the optimal donor for sensitised transplant candidates will be discussed.