Inhibitory Activity of Halogenated 3‐Benzylidenechroman‐4‐ones Against Lipopolysaccharide‐stimulated Reactive Oxygen Species Production in RAW 264.7 Macrophages. (19th May 2017)

• Record Type: Journal Article
• Authors: Thapa Magar, Til Bahadur; Kadayat, Tara Man; Oh, Hye Jin; Park, Pil‐Hoon; Lee, Eung‐Seok
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 38:Number 6(2017)
• Page Start: 665
• Page End: 670
• Publication Date: 2017-05-19
• Subjects: 4‐Chromanone -- ROS production -- Inhibitory activity -- RAW 264.7 macrophages; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.11147
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : Chromanone‐containing compounds have been reported to possess several important biological activities. As a part of our continuing effort for discovering potent anti‐inflammatory agents, a series of halogen‐containing 3‐benzylidenechroman‐4‐ones (1–15 ) were synthesized, and evaluated for their inhibitory effect on lipopolysaccharide (LPS)‐stimulated reactive oxygen species (ROS) production in RAW 264.7 macrophages. Compounds4 and10 exhibited significant inhibitory activity (IC50 = 5.09 ± 1.27 and 5.11 ± 0.51 μM, respectively) against LPS‐stimulated ROS production in RAW 264.7 macrophages. Abstract :