A new hexahydrobenzopyran derivative from the gorgonian-derived Fungus Eutypella sp. Issue 14 (18th July 2017)

• Record Type: Journal Article
• Authors: Liao, Hai-Xia; Sun, Da-Wei; Zheng, Cai-Juan; Wang, Chang-Yun
• Is Part Of: Natural product research. Volume 31:Issue 14(2017)
• Page Start: 1640
• Page End: 1646
• Publication Date: 2017-07-18
• Subjects: Gorgonian-derived fungus -- Eutypella sp -- hexahydrobenzopyran -- structure elucidation -- bioactivity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1285301
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new hexahydrobenzopyran derivative cytosporin L (1 ), and another eight known compounds were isolated from the gorgonian-derived fungus Eutypella sp. collected from the South China Sea. The structure of1 was elucidated by comprehensive spectroscopic data. The absolute configuration of1 was determined by a chemical reaction and the modified Mosher's method. The isolated secondary metabolites were evaluated for their antibacterial activities. Compound1 showed antibacterial activity towards Micrococcus lysodeikticus and Enterobacter aerogenes with the same MIC values of 3.12 μM. Compounds1 –3 were evaluated for antiviral activities. Compounds1 and2 obviously inhibited the respiratory syncytial virus (RSV) with the IC50 values of 72.01 and 30.25 μM, respectively. Abstract :