Liposomal structure: A comparative study on light scattering and chromatography techniques. Issue 11 (2nd November 2017)

• Record Type: Journal Article
• Authors: Maherani, Behnoush; Wattraint, Olivier
• Is Part Of: Journal of dispersion science and technology. Volume 38:Issue 11(2017)
• Page Start: 1633
• Page End: 1639
• Publication Date: 2017-11-02
• Subjects: ρ values -- AF4 -- light scattering technique -- molecular interaction -- nanoliposome; Emulsions -- Periodicals; Suspensions (Chemistry) -- Periodicals; Emulsions; Suspensions; 541.34
• DOI: 10.1080/01932691.2016.1269651
• Languages: English
• ISSNs: 0193-2691

Abstract

ABSTRACT: Liposomes play an important role in medical and pharmaceutical science as, nanoscale drug carriers. One of the most important features is their size and size distribution, influencing both their bio-distribution and their targeting efficiency to tumors and also therapeutic activity of liposomal antitumor drugs. In this study, the effect of preparation method and molecular interaction on size and shape of liposome was studied. The size and shape characterization of liposomes was performed by asymmetrical flow field-flow fractionation coupled online with multi-angle light scattering (AF4-MALS). The size distributions obtained by AF4-MALS were compared to mean particle sizes and size distribution measured with other standard method such as Photon Correlation Spectroscopy (PCS). Furthermore, the effect of molecular interaction (hydrophilic and hydrophobic model drugs) on liposomal structure was assessed. GRAPHICAL ABSTRACT: