Copper-catalyzed N-alkylation of indoles by N-tosylhydrazones. Issue 45 (26th May 2017)

• Record Type: Journal Article
• Authors: Ling, Li; Cao, Jing; Hu, Jianfeng; Zhang, Hao
• Is Part Of: RSC advances. Volume 7:Issue 45(2017)
• Page Start: 27974
• Page End: 27980
• Publication Date: 2017-05-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra03765a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient method for direct N -alkylation of indoles via copper-catalyzed reductive cross coupling between N -tosylhydrazones and indoles has been developed. Abstract : An efficient method for the direct N -alkylation of indoles via copper-catalyzed reductive cross coupling between N -tosylhydrazones and indole reagents has been developed. The reaction was performed in the presence of copper iodide and potassium hydroxide by utilization of tri( p -tolyl)phosphine as a ligand. A wide variety of N -alkylated indoles were obtained in moderate to good yields. The application of the current method to the synthesis of biologically active N -alkylated indole derivatives has also been demonstrated.