Gold Nanoparticles: Interference‐Free Surface‐Enhanced Raman Scattering Tags for Single‐Cell Molecular Imaging with a High Signal‐to‐Background Ratio (Small 15/2017). Issue 15 (April 2017)

• Record Type: Journal Article
• Authors: Ma, Sisi; Li, Qiang; Yin, Yongmei; Yang, Jie; Liu, Dingbin
• Is Part Of: Small. Volume 13:Issue 15(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04
• Subjects: bioimaging -- core–shell nanostructures -- gold nanoparticles -- nanoprobes -- SERS nanotags; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201770083
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 1603340, by Dingbin Liu and co‐workers, an interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.