PH-responsive magnetic micelles gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier. Issue 45 (30th May 2017)

• Record Type: Journal Article
• Authors: Su, Chao-Ming; Huang, Chen-Yu; Chen, Yao-Li; Ger, Tzong-Rong
• Is Part Of: RSC advances. Volume 7:Issue 45(2017)
• Page Start: 28207
• Page End: 28212
• Publication Date: 2017-05-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra01633f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : In the study, pH-selective magnetic targeting micelle, Gelatin- g -poly(NIPAAm- co -DMAAm- co -UA)- g -dextran/Fe3 O4 (GPDF), has been synthesized for controlled release of a hydrophilic insulin-promoting factor, nicotinamide. Abstract : pH-responsive magnetic micelles are beneficial for time-controlled and site-specific drug delivery without triggering potential biological side effects. In this study, gelatin- g -poly(NIPAAm- co -DMAAm- co -UA)- g -dextran/Fe3 O4 (GPDF) pH-responsive magnetic micelles were synthesized to carry a hydrophilic insulin-promoting factor, nicotinamide. The chemical structures were analyzed via Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. Superconducting quantum interference device (SQUID) analysis confirmed the superparamagnetic property of the GPDF micelle. The accumulative nicotinamide release under pathological pH conditions (pH 6.6) was found to be three-fold higher than that under normal pH conditions (pH 7.2). The results suggest that GPDF is beneficial for a pH-selective and magnetic target-controlled release drug delivery system.