Clinical effectiveness, cost-effectiveness and acceptability of community-based management of chronic hepatitis C: a mixed methods systematic review protocol. (April 2017)

• Record Type: Journal Article
• Authors: Pourmarzi, Davoud; Hall, Lisa; Rahman, Tony; Lim, David; FitzGerald, Gerard
• Is Part Of: JBI database of systematic reviews and implementation reports. Volume 15:Number 4(2017)
• Publication Date: 2017-04
• Subjects: Health care -- hepatitis C -- mixed methods -- primary health care; Medicine -- Periodicals; Health -- Periodicals; 613
• DOI: 10.11124/JBISRIR-2016-003103
• Languages: English
• ISSNs: 2202-4433

Abstract

Abstract : Review question/objective: The current mixed methods review aims to develop an aggregated synthesis of quantitative, qualitative and economic systematic evidence on chronic hepatitis C virus (HCV) infection management intervention delivered in community settings so as to gain an increased understanding of the clinical effectiveness, cost-effectiveness and acceptability of community-based chronic HCV management. This review will contribute to the development of a community-based chronic HCV intervention and inform clinical practice and policy discussion. The overarching question is: What is the clinical effectiveness, cost-effectiveness and acceptability of community-based programs for chronic HCV management? The sub-questions to be addressed in the review are: What is the clinical effectiveness (proportion of antiviral treatment completion and sustained virologic response) of the community-based chronic HCV management programs? What is the acceptability (treatment uptake, adherence, engagement and satisfaction) of community-based chronic HCV management programs from the perspective of involved patients? How are the models funded and are they cost-effective? What are the organizational and operational elements of the models of community-based chronic HCV management?