Should We Offer PGS to Poor Prognosis Patients Undergoing IVF? [20P]. (May 2017)

• Record Type: Journal Article
• Authors: Tulay, Pinar; Gultomruk, Meral; Findikli, Necati; Bahceci, Mustafa
• Is Part Of: Obstetrics and gynecology. Volume 129 (2017)Supplement 1
• Publication Date: 2017-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/01.AOG.0000514093.72794.43
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : INTRODUCTION: A number of complex entities, advanced maternal age (AMA), recurrent miscarriages (RM) and recurrent IVF failures (RIF), may increase the risk of numerical chromosomal abnormalities of the embryos. The aim of study was to analyze if use of aCGH for PGS improves implantation and pregnancy rates in poor prognosis patients and to analyze aneuploidy rates between embryos cultured in all-in-one time-lapse incubation (TLI) systems and standard incubators (SI) in PGS cycles. METHODS: PGS was performed for couples with at least one of the following factors; maternal age of 36 years or more, at least three previous miscarriages, at least three RIF and normal karyotype. A total of 205 embryos were biopsied at blastocyst stage. Whole genome amplification and aCGH was performed. The implantation and pregnancy rates for each group were analyzed. RESULTS: PGS results showed that 78% of the embryos obtained from poor prognosis patients were aneuploid. The implantation rate for PGS group was 11% higher compared to control group (p=0.1). The pregnancy loss rates for both PGS (28%) and control groups (23%) were similar. The rate of aneuploidy was the same for the embryos cultured in a TLI system (72%) and in a conventional incubator (72%). CONCLUSION: In this study, we have shown that poor prognosis patients develop a higher number of chromosomally abnormal embryos. We have shown that applying PGS to these patients to select a euploid blastocyst eliminates the unnecessary embryo transfer that may not result in pregnancy or lead to a miscarriage as well as improving the IVF outcome.