Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking. Issue 45 (23rd May 2017)

• Record Type: Journal Article
• Authors: Singh, Khushbu; Singh, Swati; Srivastava, Payal; Sivakumar, Sri; Patra, Ashis K.
• Is Part Of: Chemical communications. Volume 53:Issue 45(2017)
• Page Start: 6144
• Page End: 6147
• Publication Date: 2017-05-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02047c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Luminescent photostable heterometallic LnPt2 complexes were designed for their preferential nucleoli staining through formation of Pt–DNA cross-links observed through fluorescence microscopy. Abstract : Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{ cis -PtCl(NH3 )2 }2 Ln(L)(H2 O)](NO3 )2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt–DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu III or Tb III observed through confocal fluorescence microscopy.