Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity. Issue 45 (22nd May 2017)
- Record Type:
- Journal Article
- Title:
- Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity. Issue 45 (22nd May 2017)
- Main Title:
- Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity
- Authors:
- González-Vera, Juan A.
Bouzada, David
Bouclier, Céline
Eugenio Vázquez, M.
Morris, May C. - Abstract:
- Abstract : We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb 3+ ] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moiety. Abstract : We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb 3+ ] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moiety.
- Is Part Of:
- Chemical communications. Volume 53:Issue 45(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 45(2017)
- Issue Display:
- Volume 53, Issue 45 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 45
- Issue Sort Value:
- 2017-0053-0045-0000
- Page Start:
- 6109
- Page End:
- 6112
- Publication Date:
- 2017-05-22
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c6cc09948c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1098.xml