An efficient and eco-friendly synthesis of 2-pyridones and functionalized azaxanthone frameworks via indium triflate catalyzed domino reaction. Issue 11 (28th April 2017) - Poomathi, N.
Abstract : A green and efficient one-pot method has been developed for the synthesis of 2-pyridone and functionalized azaxanthone frameworks using indium triflate as an environmentally friendly, reusable catalyst. Abstract : A green and efficient one-pot method has been developed for the synthesis of 2-pyridone and functionalized azaxanthone frameworks using indium triflate as an environmentally friendly, reusable catalyst. In this one-pot reaction, 3-formylchromones display a diverse pattern of reactivity upon reaction with different classes of alkenes. An indium triflate-promoted reaction with ( Z )- N -methyl-1-(methylthio)-2-nitroethenamine leads to 3-formylchromone annulations to 2-pyridone and analogues via a remarkably facile chromone ring opening. The analogous reaction with N, N' -dimethyl-2-nitro-ethene-1, 1-diamine results in the formation of synthetically useful functionalized azaxanthones via a 6π-electrocyclization reaction.