Efficient synthesis of camptothecin propargylamine derivatives in water catalyzed by macroporous adsorption resin-supported gold nanoparticles. Issue 5 (10th February 2017)

• Record Type: Journal Article
• Authors: Zhao, Xiao-Bo; Ha, Wei; Jiang, Kan; Chen, Juan; Yang, Jun-Li; Shi, Yan-Ping
• Is Part Of: Green chemistry. Volume 19:Issue 5(2017)
• Page Start: 1399
• Page End: 1406
• Publication Date: 2017-02-10
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c6gc03119f
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Macroporous adsorption resin-supported AuNPs with excellent adsorption capacity and catalytic activity were developed for synthesizing active camptothecin derivatives in water. Abstract : In this work, for the first time, we report an efficient, simple strategy for synthesizing active camptothecin (CPT) derivatives in water. A novel macroporous adsorption resin-supported gold nanoparticle (MAR-AuNP) was first in situ prepared in water. The resulting MAR-AuNPs swell in water and were applied not only as an efficient adsorbent for hydrophobic CPT molecules, but also as a catalyst for the Mannich reaction of CPT, formaldehyde and amines with water as a solvent. A series of novel CPT propargylamine derivatives were successfully obtained with high yields by virtue of such a strategy. Moreover, the resulting CPT propargylamine derivatives exhibited excellent cytotoxicity against two different tumor cell lines. This novel and efficient strategy, avoiding the use of toxic solvents, represents a promising green route for drug discovery from natural products and shows great potential in the green pharmaceutical industry.