Catalytic enantioselective bromohydroxylation of aryl olefins with flexible functionalities. Issue 6 (2nd March 2017)

• Record Type: Journal Article
• Authors: Li, Jing; Li, Zequan; Zhang, Xun; Xu, Bing; Shi, Yian
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 6(2017)
• Page Start: 1084
• Page End: 1090
• Publication Date: 2017-03-02
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c6qo00636a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A highly enantioselective bromohydroxylation of aryl olefins with flexible functionalities has been achieved with (DHQD)2 PHAL as a catalyst and H2 O as a nucleophile, giving a variety of optically active bromohydrins with up to 98% ee. Abstract : A highly enantioselective bromohydroxylation of aryl olefins with flexible functionalities has been achieved with (DHQD)2 PHAL as a catalyst and H2 O as a nucleophile, giving a variety of optically active bromohydrins with up to 98% ee. An acid additive has been found to be beneficial for the reactivity and enantioselectivity.