Oxidative annulations triggered by a simple Lewis acid: facile synthesis of benzofurans. Issue 6 (15th February 2017)

• Record Type: Journal Article
• Authors: Sreenivasulu, Chinnabattigalla; Gopi Krishna Reddy, A.; Satyanarayana, G.
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 6(2017)
• Page Start: 972
• Page End: 977
• Publication Date: 2017-02-15
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c6qo00531d
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The first example of Lewis acid promoted efficient one-pot synthesis of benzofurans is presented. Abstract : The first example of Lewis acid promoted efficient one-pot synthesis of benzofurans is presented. Unlike previous reports on oxidative annulations between phenols and internal acetylenes, a simple and highly facile Lewis acid mediated protocol is presented. The Lewis acid (ZnCl2 ) played a crucial role to promote dual (C–H and O–H) bond formation, presumably via a six-membered cyclic transition state. Significantly, a variety of benzofurans were accomplished with symmetrical/unsymmetrical acetylenes.