A promising dual mode SPECT/CT imaging platform based on 99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles. Issue 21 (19th May 2017)

• Record Type: Journal Article
• Authors: Wen, Shihui; Zhao, Lingzhou; Zhao, Qinghua; Li, Du; Liu, Changcun; Yu, Zhibo; Shen, Mingwu; Majoral, Jean-Pierre; Mignani, Serge; Zhao, Jinhua; Shi, Xiangyang
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 21(2017)
• Page Start: 3810
• Page End: 3815
• Publication Date: 2017-05-19
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00543a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Multifunctional 99m Tc-labeled dendrimer-entrapped gold nanoparticles modified with different surface groups can be used for preferential SPECT/CT imaging of different organs. Abstract : Multifunctional 99m Tc-labeled dendrimer-entrapped gold nanoparticles ( 99m Tc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the 99m Tc-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.