Comprehensive Genetic Analysis of Pregnancy Loss by Chromosomal Microarrays: Outcomes, Benefits, and Challenges. Issue 5 (May 2017)

• Record Type: Journal Article
• Authors: Sahoo, Trilochan; Dzidic, Natasa; Strecker, Michelle N.; Commander, Sara; Travis, Mary K.; Doherty, Charles; Tyson, R. Weslie; Mendoza, Arturo E.; Stephenson, Mary; Dise, Craig A.; Benito, Carlos W.; Ziadie, Mandolin S.; Hovanes, Karine
• Is Part Of: Obstetrical & gynecological survey. Volume 72:Issue 5(2017)
• Publication Date: 2017-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000516407.08742.9c
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Genet Med 2017;19(1):83–89) High-resolution chromosomal microarray analysis (CMA) with single-nucleotide polymorphism (SNP)–based arrays is increasingly used for pediatric and prenatal diagnoses as they can simultaneously detect aneuploidies, submicroscopic chromosomal imbalances, triploidy, and regions of allelic homozygosity. Overall, 15% to 20% of clinically recognized pregnancies end in miscarriage, and approximately 1% of couples experience recurrent (at least 2) pregnancy losses.