Primary effusion lymphoma involving cerebrospinal fluid, deep cervical lymph nodes and adenoids. Report of a case supporting the lymphatic connection between brain and lymph nodes. Issue 3 (10th November 2016)

• Record Type: Journal Article
• Authors: Santonja, Carlos; Medina‐Puente, Camino; Serrano del Castillo, Cristina; Cabello Úbeda, Alfonso; Rodríguez‐Pinilla, Socorro María
• Is Part Of: Neuropathology. Volume 37:Issue 3(2017:Jun.)
• Page Start: 249
• Page End: 258
• Publication Date: 2016-11-10
• Subjects: AIDS -- Cerebrospinal fluid -- Lymphatic vessels -- Primary effusion lymphoma -- Waldeyer's ring; Nervous system -- Diseases -- Periodicals; Nervous system -- Pathophysiology -- Periodicals; 616.8047
• DOI: 10.1111/neup.12353
• Languages: English
• ISSNs: 0919-6544

Abstract

Abstract : We describe an unusual presentation of primary effusion lymphoma in CSF of a 45‐year‐old HIV‐positive man, with no evidence of involvement of pleural, peritoneal or pericardial cavities. Cytologic examination and flow cytometric analysis suggested the diagnosis, eventually made in an excised deep cervical lymph node, in which the neoplastic cells involved selectively the sinuses. This case represents the fifth reported example of CSF involvement by this type of lymphoma, and supports the alleged connection between CSF and cervical lymph nodes via lymphatic vessels. Interestingly, review of an adenoidectomy specimen obtained 9 months before presentation for nonspecific complaints showed rare clusters of neoplastic cells involving surface epithelium and chorium, a finding that might represent a homing mechanism and implies an asymptomatic, occult phase of lymphoma development.