Higher Level of Oxidative Stress Markers in Small for Gestational Age Newborns Delivered by Cesarean Section at Term. (4th May 2017)

• Record Type: Journal Article
• Authors: Dede, Hulya; Takmaz, Ozguc; Ozbasli, Esra; Dede, Suat; Gungor, Mete
• Is Part Of: Fetal and pediatric pathology. Volume 36:Number 3(2017)
• Page Start: 232
• Page End: 239
• Publication Date: 2017-05-04
• Subjects: Oxidative stress -- small for gestational age -- cesarean section -- superoxide dismutase -- malondialdehyde; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2017.1303860
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Introduction : The aim of our study was to determine lipid peroxidation products and antioxidant enzyme activity in umbilical cord blood of small for gestational age (SGA) neonates. Materials and methods : Umbilical cord arterial blood samples were collected from 21-term singleton SGA newborn infants and 21 age- and sex-matched appropriate for gestational age (AGA) term neonates prospectively born by elective cesarean section for determination of malondialdehyde (MDA) as a marker of lipid peroxidation and superoxide dismutase (SOD) for antioxidant activity. Results : MDA levels were increased (5.20 vs. 3.52 nmol/mL; p < 0.001), while levels of SOD (6.24 vs. 8.99 U/mL; p < 0.01) were decreased in SGA neonates when compared with AGA newborn infants. Conclusions : Elevated MDA levels and decreased SOD activity in umbilical cord blood may show the possibility of insufficient protective mechanisms against increased oxidative stress in SGA neonates born by cesarean section.