Cu(OTf)2‐Catalyzed Dehydrogenative C–H Activation under Atmospheric Oxygen: An Expedient Approach to Pyrrolo[3, 2‐d]pyrimidine Derivatives. Issue 21 (5th June 2013)

• Record Type: Journal Article
• Authors: Roy, B.; Hazra, Somjit; Mondal, Biplab; Majumdar, K. C.
• Is Part Of: European journal of organic chemistry. Issue 21(2013)
• Page Start: 4570
• Page End: 4577
• Publication Date: 2013-06-05
• Subjects: Synthetic methods -- Cycli­zation -- Copper -- Fused‐ring systems -- Nitrogen heterocycles -- Nucleobases; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201300275
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A new dehydrogenative C–H activation of uracil in an open atmosphere was developed to synthesize pyrrolo‐pyrimidines, which are potentially bioactive molecules. This new approach establishes the selective catalytic activity of Cu(OTf)2 to accomplish the uracil C‐6–H activation. Abstract : A new approach to pyrrolo[3, 2‐ d ]pyrimidine derivatives was accomplished through a dehydrogenative C–H activation of uracil in the open atmosphere with Cu(OTf)2 as a catalyst. This method features mild reaction conditions and operational simplicity. The use of K2 CO3 as a base significantly improves the yield of the reaction.