An empirical method for reducing variability and complexity of myocardial perfusion quantification by dual bolus cardiac MRI. Issue 6 (8th September 2016)
- Record Type:
- Journal Article
- Title:
- An empirical method for reducing variability and complexity of myocardial perfusion quantification by dual bolus cardiac MRI. Issue 6 (8th September 2016)
- Main Title:
- An empirical method for reducing variability and complexity of myocardial perfusion quantification by dual bolus cardiac MRI
- Authors:
- Chatterjee, Neil
Benefield, Brandon C.
Harris, Kathleen R.
Fluckiger, Jacob U.
Carroll, Timothy
Lee, Daniel C. - Abstract:
- Abstract : Purpose: Myocardial perfusion can be quantified using the "dual bolus" technique, which uses two separate contrast boluses to avoid signal nonlinearity in the blood pool. This technique relies on knowing the precise ratio of contrast concentrations between the two boluses. In this study, we investigated the variability found in these ratios, as well as the error it introduces, and developed a method for correction. Methods: Five dogs received dual bolus myocardial perfusion MRI scans. Perfusion was calculated separately using assumed contrast dilution ratios and empirically determined contrast ratios. Perfusion was compared with reference standard fluorescent microspheres. The same technique was then applied to a cohort of six patients with no significant coronary artery stenosis by cardiac catheterization. Results: Assumed contrast dilution ratios were 10:1 for all animal and patient scans. Empirically derived contrast ratios were significantly different for animal (8.51:1 ± 1.53:1, P < 0.001) and patient scans (7.32:1 ± 2.27:1, P < 0.01). Incorporating empirically derived ratios for animal scans improved correlation with microspheres from 0.84 to 0.90 ( P < 0.05). Conclusion: Variability in dual bolus contrast concentration ratios is an important source of experimental error, especially outside of a carefully controlled laboratory setting. Empirically deriving the correct ratio is feasible and improves the accuracy of quantitative perfusion measurements. MagnAbstract : Purpose: Myocardial perfusion can be quantified using the "dual bolus" technique, which uses two separate contrast boluses to avoid signal nonlinearity in the blood pool. This technique relies on knowing the precise ratio of contrast concentrations between the two boluses. In this study, we investigated the variability found in these ratios, as well as the error it introduces, and developed a method for correction. Methods: Five dogs received dual bolus myocardial perfusion MRI scans. Perfusion was calculated separately using assumed contrast dilution ratios and empirically determined contrast ratios. Perfusion was compared with reference standard fluorescent microspheres. The same technique was then applied to a cohort of six patients with no significant coronary artery stenosis by cardiac catheterization. Results: Assumed contrast dilution ratios were 10:1 for all animal and patient scans. Empirically derived contrast ratios were significantly different for animal (8.51:1 ± 1.53:1, P < 0.001) and patient scans (7.32:1 ± 2.27:1, P < 0.01). Incorporating empirically derived ratios for animal scans improved correlation with microspheres from 0.84 to 0.90 ( P < 0.05). Conclusion: Variability in dual bolus contrast concentration ratios is an important source of experimental error, especially outside of a carefully controlled laboratory setting. Empirically deriving the correct ratio is feasible and improves the accuracy of quantitative perfusion measurements. Magn Reson Med 77:2347–2355, 2017. © 2016 International Society for Magnetic Resonance in Medicine … (more)
- Is Part Of:
- Magnetic resonance in medicine. Volume 77:Issue 6(2017)
- Journal:
- Magnetic resonance in medicine
- Issue:
- Volume 77:Issue 6(2017)
- Issue Display:
- Volume 77, Issue 6 (2017)
- Year:
- 2017
- Volume:
- 77
- Issue:
- 6
- Issue Sort Value:
- 2017-0077-0006-0000
- Page Start:
- 2347
- Page End:
- 2355
- Publication Date:
- 2016-09-08
- Subjects:
- Nuclear magnetic resonance -- Periodicals
Electron paramagnetic resonance -- Periodicals
616.07548 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-2594 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/mrm.26326 ↗
- Languages:
- English
- ISSNs:
- 0740-3194
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5337.798000
British Library DSC - BLDSS-3PM
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- 2103.xml