Sequential development of peripheral t-cell lymphoma post immunochemotherapy of diffuse large B cell lymphoma. Issue 4 (3rd April 2017)

• Record Type: Journal Article
• Authors: Wang, Jing-Wen; Chen, Jia-Yan; Lu, Chen; Tang, Xi
• Is Part Of: Cancer biology & therapy. Volume 18:Issue 4(2017)
• Page Start: 201
• Page End: 202
• Publication Date: 2017-04-03
• Subjects: Diffuse large B-cell lymphoma -- discordant lymphoma -- peripheral t-cell lymphoma; 616.99406
• DOI: 10.1080/15384047.2017.1294293
• Languages: English
• ISSNs: 1538-4047

Abstract

ABSTRACT: Reports of sequential occurrence of two or more types of lymphoma are rare, especially when they involve different cell lineages. Herein, we report a rare case of sequential development of peripheral t-cell lymphoma following treatment of diffuse large B cell lymphoma. In a 73-year-old Chinese male patient, diffuse large B-cell lymphoma (DLBCL) was diagnosed in September 2011 based on the result of a tongue biopsy. Afterwards, he received rituximab combined with chemotherapy and local radiotherapy. Though he achieved completed remission, he had a new symptom of one enlarged left inguinal lymph node in November of 2015. A new biopsy was then performed. Immunohistochemistry and polymerase chain reaction (PCR) for gene rearrangements proved monoclonal T-cell lymphoma. We didn't detect EBV infection in either of two biopsies, nor any evidence of immune dysfunction complications. Sequential development of B-cell and T-cell malignancy in this patient maybe an example of treatment-related secondary lymphoma.