The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates. (3rd July 2017)

• Record Type: Journal Article
• Authors: Boskabadi, Hassan; Zakerihamidi, Maryam; Heidarzadeh, Mohammad; Avan, Amir; Ghayour-Mobarhan, Majid; Ferns, Gordon A.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 13(2017)
• Page Start: 1556
• Page End: 1561
• Publication Date: 2017-07-03
• Subjects: Asphyxia -- hypoxic ischemic encephalopathy -- newborn -- PAB balance; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1209655
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : Asphyxia is a major cause of disabilities in term-born infants. Here we have explored the value in HIE (hypoxic-ischemic-encephalopathy) of using a combination of serum pro-oxidant/antioxidant balance (PAB) assay for predicting the prognosis of asphyxia. Method : Ninety term neonates with asphyxia were enrolled and followed up for two years. Serum PAB, demographic/biochemical characteristics of mothers, and their neonates were determined. The Denver II test was used to assess outcomes. Results : Of the 90 asphyxiated neonates, 47 (52.2%) had a normal outcome and 43 babies (47.8%) had abnormal outcome. Serum PAB levels in neonates with normal and abnormal outcomes were 17.1 ± 9.23 and 48.27 ± 41.30 HK, respectively. A combination of HIE intensity and PAB, compared to other indicators, had a higher predictive-value (95.2%) for outcomes in asphyxiated babies. Conclusion : We demonstrate that PAB in combination with HIE grade may have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants.