Enhanced Reaction Efficiency in Continuous Flow. Issue 3 (3rd November 2016)

• Record Type: Journal Article
• Authors: Morse, Peter D.; Beingessner, Rachel L.; Jamison, Timothy F.
• Is Part Of: Israel journal of chemistry. Volume 57:Issue 3/4(2017)
• Page Start: 218
• Page End: 227
• Publication Date: 2016-11-03
• Subjects: flow chemistry -- process intensification -- microreactors -- photochemistry -- synthesis design; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.201600095
• Languages: English
• ISSNs: 0021-2148

Abstract

Abstract: Continuous flow reactors are enabling tools that can significantly benefit chemical reactions, especially those that are path length dependent (e.g., photochemical), mixing or transport dependent (e.g., gas‐liquid), exothermic, or utilize hazardous or unstable intermediates. In this review, it is demonstrated how the nearly instantaneous mixing, exceptionally fast mass transfer, safe access to high temperatures and pressures, and high surface area to volume ratio can be leveraged to improve product yield, reaction rates and/or selectivity. By showcasing five synthetic methodologies examined by our group, it is hoped that the reader will gain an appreciation of the accessible and transformative nature of flow chemistry for improving existing transformations, enabling rapid optimization, and for developing new methodologies that depend on precise parameter controls. Abstract :