IL‐17 and IL‐22 in immunity: Driving protection and pathology. Issue 4 (7th April 2017)

• Record Type: Journal Article
• Authors: Eyerich, Kilian; Dimartino, Valentina; Cavani, Andrea
• Is Part Of: European journal of immunology. Volume 47:Issue 4(2017)
• Page Start: 607
• Page End: 614
• Publication Date: 2017-04-07
• Subjects: autoimmune diseases -- cytokines -- Th17 -- Th22; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201646723
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : IL‐17 and IL‐22 exert protective functions in boundary organs such as skin, lung, and gastrointestinal tract. However, an imbalance of the orchestrated tissue‐signaling system might result in autoimmune diseases, promote cancer growth or predispose to infectious diseases. Abstract : IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro‐inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue‐signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double‐faceted cytokines IL‐17 and IL‐22.