A systematic review examining quality of life following pelvic exenteration for locally advanced and recurrent rectal cancer. (May 2017)

• Record Type: Journal Article
• Authors: Rausa, E.; Kelly, M. E.; Bonavina, L.; O'Connell, P. R.; Winter, D. C.
• Is Part Of: Colorectal disease. Volume 19:Number 5(2017)
• Page Start: 430
• Page End: 436
• Publication Date: 2017-05
• Subjects: Rectal cancer -- pelvic exenteration -- recurrent neoplasm -- quality of life -- surgical outcomes; Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.13647
• Languages: English
• ISSNs: 1462-8910

Abstract

Abstract: Aim: Pelvic exenteration is a complex surgical procedure associated with considerable morbidity. Quality of life (QoL) is a crucial metric of surgical outcome. The aim of this review was to assess the QoL following pelvic exenteration for locally advanced rectal cancer (LARC) and local recurrent rectal cancer (LRRC). Method: A comprehensive search of studies published between 2000 and 2016 that examined QoL outcome following pelvic exenteration was performed. Functional Assessment of Cancer Therapy – Colorectal (FACT‐C), SF‐36 version 2, European Organization for Research and Treatment of Cancer QLQ‐C30, and Brief Pain Inventory assessments from these studies were reviewed. Results: Seven studies reporting on 382 patients were included. Baseline QoL was the strongest predictor of postoperative QoL. Female gender, total pelvic exenteration with or without bone resection, and positive surgical margins were associated with a reduced QoL. In the majority of patients, QoL gradually improved between 2 and 9 months post‐operation. Conclusion: QoL is an important patient‐reported outcome. This review highlights factors associated with reduced postoperative QoL that should be borne in mind when surgical resection is being considered.