Synthesis of C2‐Symmetric Diphosphormonoamidites and Their Use as Ligands in Rh‐Catalyzed Hydroformylation: Relationships between Activity and Hydrolysis Stability. Issue 2 (23rd January 2017)

• Record Type: Journal Article
• Authors: Morales Torres, Galina; Behrens, Stephan; Michalik, Dirk; Selent, Detlef; Spannenberg, Anke; Lühr, Susan; Dyballa, Katrin Marie; Franke, Robert; Börner, Armin
• Is Part Of: ChemistryOpen. Volume 6:Issue 2(2017)
• Page Start: 247
• Page End: 253
• Publication Date: 2017-01-23
• Subjects: diphosphoramidites -- hydroformylation -- regioselectivity -- rhodium -- structure–activity relationships; Chemistry -- Periodicals; 540; 540.5
• DOI: 10.1002/open.201600152
• Languages: English
• ISSNs: 2191-1363

Abstract

Abstract: A series of diphosphoramidites has been synthetized with a piperazine, homopiperazine, and an acyclic 1, 2‐diamine unit in the backbone. New compounds were tested alongside related N ‐acyl phosphoramidites as ligands in the Rh‐catalyzed hydroformylation of n ‐octenes to investigate their influence on the activity and regioselectivity. A subsequent study of their hydrolysis stability revealed that the most stable ligands induced the highest activity in the catalytic reaction. Abstract : Stability versus reactivity : Diphosphoramidites that are highly resistant towards hydrolysis and also perform highly efficiently as monodentate ligands in rhodium‐catalyzed hydroformylation of n ‐octene mixtures have been prepared.