Pulmonary and hepatic eosinophilic granulomas and epistaxis in a horse suggestive of multi‐systemic eosinophilic epitheliotropic disease. (12th March 2013)

• Record Type: Journal Article
• Authors: Horan, E. M.; Metcalfe, L. V. A.; de Swarte, M.; Cahalan, S. D.; Katz, L. M.
• Is Part Of: Equine veterinary education. Volume 25:Number 12(2013:Dec.)
• Page Start: 607
• Page End: 613
• Publication Date: 2013-03-12
• Subjects: horse -- lungs -- eosinophilic granulomas -- multi‐systemic eosinophilic epitheliotropic disease -- epistaxis; Horses -- Diseases -- Periodicals; Horses -- Diseases -- Treatment -- Periodicals; 636.108905
• DOI: 10.1111/eve.12017
• Languages: English
• ISSNs: 0957-7734

Abstract

Summary: Multi‐systemic eosinophilic epitheliotropic disease (MEED) is a relatively uncommon disease characterised by eosinophilic infiltration of more than one organ system, with the skin and gastrointestinal tract most commonly affected. This case report describes a gelding that presented for weight loss, increased respiratory rate and effort and chronic intermittent epistaxis. During post mortem examination diffuse eosinophilic granulomatous lesions were identified in the lung and liver, leading to a diagnosis of MEED. Veno‐occlusive pulmonary remodelling was also discovered, believed to be the cause of the chronic epistaxis and a result of the pulmonary fibrosis and eosinophilic granulomas. Abstract : See also Clinical Commentary by Pucheu‐Haston and Del Piero