Measurement of interleukin-6 (IL-6) and erythropoietin (EPO) in umbilical cords of preterm infants with intraventricular hemorrhage in two hospitals in Tehran. (3rd August 2017)

• Record Type: Journal Article
• Authors: Khosravi, Nastaran; Badamchi, Ali; Khalesi, Nasrin; Tabatabaee, Azardokht; Naghdalipour, Mehri; Asgarian, Ramin
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 15(2017)
• Page Start: 1847
• Page End: 1850
• Publication Date: 2017-08-03
• Subjects: Interleukin-6 -- erythropoietin -- umbilical cord plasma -- intraventricular hemorrhage -- premature infant; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1228055
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Background : Intraventricular hemorrhage (IVH) is an important cause of death in premature infants. This study aimed to assess the association of the umbilical cord plasma levels of interleukin-6 (IL-6) and erythropoietin (EPO) with the occurrence and severity of IVH in premature infants. Methods : Fifty premature newborns of mothers with chorioamnionitis risk factor were selected via nonprobability sampling. The concentration of the cord plasma's IL-6 and erythropoietin were measured by enzyme-linked immunosorbent assay (ELISA) for 3 days. Finally, all samples underwent sonography for the diagnosis of IVH. Results analyzed statistically. Results : Among the samples, 68.98% of them were diagnosed with IVH grade 1. The most severe IVH cases were detected on the second day. The mean and standard deviation of IL-6 level was 74.71 ± 50.53 in the case group and 24.10 ± 46.10 in the control group. There was a correlation between IL-6 levels and IVH ( p = 0.0005). The mean and standard deviation of EPO level was 18.38 ± 15.23 in the IVH group and 6.45 ± 13.48 in samples without IVH. A correlation was detected between EPO level and IVH ( p = 0.005). Conclusion : The concentration of IL-6 and EPO levels of the cord plasma was higher in the premature newborns with IVH.