Functional oligopeptide as a novel strategy for drug delivery. (9th August 2017)

• Record Type: Journal Article
• Authors: Ji, Yujie; Qiao, Hongzhi; He, Jiayu; Li, Weidong; Chen, Rui; Wang, Jingjing; Wu, Li; Hu, Rongfeng; Duan, Jinao; Chen, Zhipeng
• Is Part Of: Journal of drug targeting. Volume 25:Number 7(2017)
• Page Start: 597
• Page End: 607
• Publication Date: 2017-08-09
• Subjects: Oligopeptide -- stimuli-responsive -- self-assemble -- targeting -- functional; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.1080/1061186X.2017.1309044
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Oligopeptides, a type of short peptide, which consist of 2–20 amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the environment. In this review, we aim to highlight the importance of functional oligopeptides for nanomedical applications and put forward the views on the future development direction of oligopeptide medicines. Oligopeptides have gained wide attentions due to their inherent properties, but the lack of understanding the mechanisms of in vivo transport behavior is the biggest problem and challenge at the present stage. Therefore, it is an important direction for the future clinical research to systematically evaluate its metabolic behavior and safety in vivo .