Reinstatement of pain-related brain activation during the recognition of neutral images previously paired with nociceptive stimuli. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Forkmann, Katarina; Wiech, Katja; Sommer, Tobias; Bingel, Ulrike
• Is Part Of: Pain. Volume 156:Issue 8(2015)
• Publication Date: 2015-08
• Subjects: fMRI -- Experimental pain -- Reinstatement -- Reactivation; Pain -- Periodicals; Douleur -- Périodiques; Anesthésie -- Périodiques; Pain; Electronic journals; Periodicals; Electronic journals; 616.0472
• DOI: 10.1097/j.pain.0000000000000194
• Languages: English
• ISSNs: 0304-3959

Abstract

Abstract : Abstract: Remembering an event partially reactivates cortical and subcortical brain regions that were engaged during its experience and encoding. Such reinstatement of neuronal activation has been observed in different sensory systems, including the visual, auditory, olfactory, and somatosensory domain. However, so far, this phenomenon of incidental memory has not been explored in the context of pain. In this functional magnetic resonance imaging study, we investigated the neural reinstatement of pain-related and tone-related activations during the recognition of neutral images that had been encoded during (1) painful stimulation, (2) auditory stimulation of comparable unpleasantness, or (3) no additional stimulation. Stimulus-specific reinstatement was tested in 24 healthy male and female participants who performed a visual categorization task (encoding) that was immediately followed by a surprise recognition task. Neural responses were acquired in both sessions. Our data show a partial reinstatement of brain regions frequently associated with pain processing, including the left posterior insula, bilateral putamen, and right operculum, during the presentation of images previously paired with painful heat. This effect was specific to painful stimuli. Moreover, the bilateral ventral striatum showed stronger responses for remembered pain-associated images as compared with tone-associated images, suggesting a higher behavioral relevance of remembering neutral pictures previously paired with pain. Our results support the biological relevance of pain in that only painful but not equally unpleasant auditory stimuli were able to "tag" neutral images during their simultaneous presentation and reactivate pain-related brain regions. Such mechanisms might contribute to the development or maintenance of chronic pain and deserve further investigation in clinical populations. Abstract : Neutral images previously presented with painful heat in an encoding task elicited reactivations of pain-associated brain regions during their recognition in healthy subjects.