Inhibition of type I interferon induction and signalling by mosquito‐borne flaviviruses. (22nd March 2017)

• Record Type: Journal Article
• Authors: Cumberworth, Stephanie L.; Clark, Jordan J.; Kohl, Alain; Donald, Claire L.
• Is Part Of: Cellular microbiology. Volume 19:Number 5(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-03-22
• Subjects: Flavivirus -- interferon antagonists -- sfRNA -- type I interferon; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.12737
• Languages: English
• ISSNs: 1462-5814

Abstract

Summary: The Flavivirus genus ( Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito‐borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.