Modeling Suspension Cultures of Microbial and Mammalian Cells with an Adaptable Six‐Compartment Model. Issue 5 (6th April 2017)

• Record Type: Journal Article
• Authors: Brüning, Simone; Gerlach, Inga; Pörtner, Ralf; Mandenius, Carl-Fredrik; Hass, Volker C.
• Other Names: Obalová Lucie guestEditor.
• Is Part Of: Chemical engineering & technology. Volume 40:Issue 5(2017)
• Page Start: 956
• Page End: 966
• Publication Date: 2017-04-06
• Subjects: Compartment models -- Fungi -- Mammalian cells -- Microorganisms -- Suspension cultivation; Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201600639
• Languages: English
• ISSNs: 0930-7516

Abstract

Abstract: Process models can be used for model‐based control strategies, but model development is a time‐consuming and laborious task. To reduce the modeling effort, a new structured compartment model was developed, which may easily be adapted to different cultivation processes. The proposed six‐compartment model was used to describe the time courses of cultivations of bacteria, yeast, fungi, and mammalian cell lines, namely, Escherichia coli, Lactobacillus delbrueckii, Saccharomyces cerevisiae, Cyathus striatus, and a hybridoma mammalian cell line. The model can describe the time courses of important state variables and can be adapted to the cultivation processes by parameterization. This reduces the modeling effort for a new process significantly. Abstract : The development of process models can be time consuming and laborious. To remedy this, a highly adaptable six‐compartment model has been created, which is able to describe the time courses of important state variables and the growth behavior of bacteria, yeast, fungi, and animal cells. The model can be adapted to a new process by parameter estimation. This reduces the modeling effort significantly.