Attenuated Low‐Grade Inflammation Following Long‐Term Dietary Intervention in Postmenopausal Women with Obesity. Issue 5 (May 2017)

• Record Type: Journal Article
• Authors: Blomquist, Caroline; Alvehus, Malin; Burén, Jonas; Ryberg, Mats; Larsson, Christel; Lindahl, Bernt; Mellberg, Caroline; Söderström, Ingegerd; Chorell, Elin; Olsson, Tommy
• Is Part Of: Obesity. Volume 25:Issue 5(2017)
• Page Start: 892
• Page End: 900
• Publication Date: 2017-05
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21815
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: Abdominal fat accumulation after menopause is associated with low‐grade inflammation and increased risk of metabolic disorders. Effective long‐term lifestyle treatment is therefore needed. Methods: Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic‐type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation‐related parameters. Results: Android fat decreased significantly more in the PD group ( P = 0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long‐term significant effects ( P < 0.001) on adipose gene expression were found for toll‐like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL‐6) and tumor necrosis factor α levels were decreased at 24 months in both groups ( P < 0.001) with a significant diet‐by‐time interaction for serum IL‐6 ( P = 0.022). High‐sensitivity C‐reactive protein was decreased in the PD group at 24 months ( P = 0.001). Conclusions: A reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation‐related adipose gene expression.