A case of the pleomorphic adenoma of minor salivary gland that resulted in maxillary metastasis 20 years after primary tumor resection. Issue 2 (March 2017)

• Record Type: Journal Article
• Authors: Taketomi, Takaharu; Todoroki, Keita; Ogata, Kinuko; Abe, Yushi; Koga, Makoto; Kusukawa, Jingo
• Is Part Of: Journal of oral and maxillofacial surgery, medicine, and pathology. Volume 29:Issue 2(2017)
• Page Start: 136
• Page End: 141
• Publication Date: 2017-03
• Subjects: Metastasizing pleomorphic adenoma (MPA) -- Benign tumor -- Minor salivary gland; Mouth -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Oral medicine -- Periodicals; Mouth -- Diseases -- Pathogenesis -- Periodicals; Surgery, Oral -- Periodicals; Oral Medicine -- Periodicals; Pathology, Oral -- Periodicals; Face -- Surgery; Maxilla -- Surgery; Mouth -- Diseases -- Pathogenesis; Mouth -- Surgery; Oral medicine; Electronic journals -- Sciences; Electronic journals -- Medicine; Periodicals; 617.522059
• DOI: 10.1016/j.ajoms.2016.08.009
• Languages: English
• ISSNs: 2212-5566

Abstract

Abstract: Metastasizing pleomorphic adenoma (MPA) is a rare neoplasm of the salivary glands, and the metastatic foci are histologically identical to the benign tumor. The minor salivary glands are rarely the origin of MPA. We describe the case of a 63-year-old woman with maxillary MPA occurring 20 years after primary resection for PA that originated in the minor salivary gland of the hard palate. The metastatic site was bilateral maxillary bone, and we performed tumor resection in combination with Le Fort I osteotomy. The metastatic deposits resembled benign PA of the primary lesion with no histological evidence of malignancy. In addition to this case, we undertook a review of the literature about all identified MPA cases that the minor salivary gland origin reported in the English language up to 2015. The most frequent primary site was the palate (66.7%), and the most frequent metastatic site was the cervical lymph nodes (33.3%). The mean interval from primary tumor to metastasis was 8.9 years and all cases were treated with surgical resection for MPA, except for one. PA should be followed up with consideration of metastasis over the long term.