Circulating tumor cells and miRNAs as prognostic markers in neuroendocrine neoplasms. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Zatelli, Maria Chiara; Grossrubatscher, Erika Maria; Guadagno, Elia; Sciammarella, Concetta; Faggiano, Antongiulio; Colao, Annamaria
• Is Part Of: Endocrine-related cancer. Volume 24:Issue 6(2017)
• Page Start: R223
• Page End: R237
• Publication Date: 2017-06
• Subjects: neuroendocrine tumors -- circulating biomarkers -- prognosis -- miRNA -- CTC; Endocrine glands -- Cancer -- Periodicals; Endocrinology -- Periodicals; Cancer -- Endocrine aspects -- Periodicals; 616.9944005
• DOI: 10.1530/ERC-17-0091
• Languages: English
• ISSNs: 1351-0088

Abstract

Abstract : The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. This review summarizes the available data on the possible role of circulating tumor cells and microRNAs as prognostic markers in NENs.