Stem cells for tissue engineered vascular bypass grafts. (4th July 2017)

• Record Type: Journal Article
• Authors: Askari, Forough; Solouk, Atefeh; Shafieian, Mehdi; Seifalian, Alexander M.
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 5(2017)
• Page Start: 999
• Page End: 1010
• Publication Date: 2017-07-04
• Subjects: Artery -- blood vessels -- scaffold -- stem cells -- tissue engineering -- vascular bypass grafts; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2016.1198366
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Despite great advances in tissue engineering, there have been very few reports on the successful clinical use of small-diameter tissue-engineered vascular grafts (TEVGs). Small-diameter (<6 mm internal diameter) is considered as unmet clinical need. This review critically examines the role of stem cells that have been proposed and used in development of TEVGs, and assesses the viability of such graft to clinical pathway. With over 20 years of expertise in development of bypass graft and a number of grafts under clinical trial, this team will offer potential areas for future research that may help improve the current state-of-the-art technology.