Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review. (24th July 2017)

• Record Type: Journal Article
• Authors: Pohanka, Miroslav; Martinkova, Pavla; Brtnicky, Martin; Kynicky, Jindrich
• Is Part Of: Toxicology mechanisms and methods. Volume 27:Number 6(2017)
• Page Start: 408
• Page End: 416
• Publication Date: 2017-07-24
• Subjects: Oxidative stress -- mustard gas -- sulfur mustard -- inflammation -- poly(ADP-ribose) polymerase -- antioxidant -- bis(2-chloroethyl)sulfide; Analytical toxicology -- Periodicals; Toxicology -- Periodicals; Toxicology -- Methodology -- Periodicals; 615.907
• DOI: 10.1080/15376516.2017.1320695
• Languages: English
• ISSNs: 1537-6516

Abstract

Abstract: Sulfur mustard, in a chemical name bis(2-chloroethyl) sulfide, is a chemical warfare agent. It is cytotoxic and blister forming once spread over the skin. Though exact molecular mechanism of sulfur mustard toxic action remains unknown, inflammation and oxidative stress development are considered as the most relevant pathological consequences. Applications of either low-molecular weight antioxidants or cofactors for enzymatic antioxidants are considered as suitable ways how to ameliorate the poisoning. In this article, survey of literature on countermeasures against sulfur mustard poisoning are given and evidence of oxidative stress role during sulfur mustard poisoning and availability of antioxidants for the therapy are discussed.