Diglycosidic indole alkaloid derivatives from an aqueous extract of Isatis indigotica roots. Issue 6 (3rd June 2017)

• Record Type: Journal Article
• Authors: Meng, Ling-Jie; Guo, Qing-Lan; Xu, Cheng-Bo; Zhu, Cheng-Gen; Liu, Yu-Feng; Chen, Ming-Hua; Lin, Sheng; Li, Yu-Huan; Jiang, Jian-Dong; Shi, Jian-Gong
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 6(2017)
• Page Start: 529
• Page End: 540
• Publication Date: 2017-06-03
• Subjects: Cruciferae -- Isatis indigotica -- indole alkaloid diglycoside -- isatigotindolediosides A-F -- antiviral activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1320547
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Six new indole alkaloid diglycosides named isatigotindolediosides A-F (1–6 ), along with three known analogs (7–9 ), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures including the absolute configurations were determined by comprehensive spectroscopic data analysis, combined with enzyme or acid hydrolysis, and comparison of experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. In the preliminary assays, compounds3, 5, and8 showed antiviral activity against Coxsackie virus B3. Abstract :