Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp. SCSIO XWS03F03. Issue 7 (3rd July 2017)

• Record Type: Journal Article
• Authors: Wang, Ying; Lin, Xiu-Ping; Ju, Zhi-Ran; Liao, Xiao-Jian; Huang, Xiao-Jun; Zhang, Chen; Zhao, Bing-Xin; Xu, Shi-Hai
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 7(2017)
• Page Start: 684
• Page End: 690
• Publication Date: 2017-07-03
• Subjects: Aspergillus sp. SCSIO XWS03F03 -- polyketides -- antimicrobial; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1231673
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new polyketides, aspergchromones A (1 ) and B (2 ), together with five known compounds, secalonic acid D (3 ), noreugenin (4 ), (3 S )-5-hydroxymellein (5 ), (4 S )-6-hydroxyisosclerone (6 ), and (-)-regiolone (7 ), were isolated from the ethyl acetate extract of marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound3 showed moderate antimicrobial activity.