Microbial transformation of the anti-diabetic agent corosolic acid by Cunninghamella echinulata. Issue 7 (3rd July 2017)

• Record Type: Journal Article
• Authors: Feng, Xu; Lu, Yan-Hua; Liu, Zhen; Li, Dai-Ping; Zou, Ying-Xin; Fang, Yi-Qun; Chu, Zhi-Yong
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 7(2017)
• Page Start: 645
• Page End: 650
• Publication Date: 2017-07-03
• Subjects: Triterpenoid -- biotransformation -- corosolic acid -- anti-diabetic -- Cunninghamella echinulata; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1187140
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The pentacyclic triterpenoid corosolic acid was metabolized by Cunninghamella echinulata CGMCC 3.2000 to its C-24 aldehyde group metabolite and five other hydroxylated metabolites: madasiatic acid (2 ), 2α, 3β, 7β-trihydroxyurs-12-en-28-oic acid (3 ), 2α, 3β, 15α-trihydroxyurs-12-en-28-oic acid (4 ), 2α, 3β, 6β, 7β-tetrahydroxyurs-12-en-28-oic acid (5 ), 2α, 3β, 7β, 15α-tetrahydroxyurs-12-en-28-oic acid (6 ), and 2α, 3β, 7β-trihydroxy-24-al-urs-12-en-28-oic acid (7 ); compounds3, 5, and7 were new compounds. The α -glucosidase inhibitory effects of the metabolites were also evaluated.