Elevated Serum Levels of Interleukin-17A in Uveitis Patients. (14th August 2013)

• Record Type: Journal Article
• Authors: Jawad, Shayma; Liu, Baoying; Agron, Elvira; Nussenblatt, Robert B.; Sen, H. Nida
• Is Part Of: Ocular immunology and inflammation. Volume 21:Number 6(2013)
• Page Start: 434
• Page End: 439
• Publication Date: 2013-08-14
• Subjects: Cytokine -- interleukin 17 -- serum, Th17 -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2013.815786
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : T helper 17 cells (Th17) are one of the main pathogenic effectors in autoimmune uveitis, and IL-17A is the signature cytokine of Th17 cells. This study aims to assess serum IL-17A levels in patients with autoimmune uveitis and evaluate associations between IL-17A levels and disease characteristics. Methods : Serum IL-17A levels from 87 autoimmune uveitis patients and 60 healthy controls were assessed using an enzyme-linked immunosorbent assay. Among this cohort, 9 patients were followed longitudinally for IL-17A levels during active and inactive stages of their disease. Results : Median serum IL-17A levels were higher among uveitis patients compared to controls ( p < 0.0001). Moreover, IL-17A levels were elevated among uveitis patients with active disease compared to those with inactive disease ( p = 0.0202). Among the 9 patients followed longitudinally, IL-17A levels were elevated during active disease compared to the inactive stage ( p = 0.0078). Conclusions : Serum IL-17A levels are elevated in uveitis patients, particularly in active uveitis.