Noniatrogenic Neonatal Gastric Perforation: The Role of Interstitial Cells of Cajal. (1st December 2013)

• Record Type: Journal Article
• Authors: Jactel, Samuel Noah; Abramowsky, Carlos R.; Schniederjan, Matthew; Durham, Megan M.; Ricketts, Richard R.; Clifton, Matthew S.; Langberg, Karl M.; Elawabdeh, Nancy; Pandya, Samir; Talebagha, Sarah; Shehata, Bahig M.
• Is Part Of: Fetal and pediatric pathology. Volume 32:Number 6(2013)
• Page Start: 422
• Page End: 428
• Publication Date: 2013-12-01
• Subjects: neonatal gastric perforation (NGP) -- interstitial cells of Cajal (ICC) -- c-Kit -- CD117; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2013.799248
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract : Noniatrogenic neonatal gastric perforation is a rare and life-threatening condition whose etiology is often unclear. Interstitial cells of Cajal act as gastrointestinal pacemaker cells and express the proto-oncogene c-Kit. Six new cases were identified at our institution which presented with no mechanical, pharmacologic, or otherwise medical-related intervention prior to rupture. The number of interstitial cells of Cajal in nonnecrotic muscularis propria from five random high-power fields per specimen was compared using immunohistochemical stains for c-Kit. The authors show that a lack of interstitial cells of Cajal in the stomach musculature may be implicated in the development of noniatrogenic gastric perforation ( p = 0.008). Further large-scale studies, including molecular and genetic analysis, may help to better understand this phenomenon.