Ordinary differential equations and Boolean networks in application to modelling of 6-mercaptopurine metabolism. Issue 4 (12th April 2017)

• Record Type: Journal Article
• Authors: Lavrova, Anastasia I.; Postnikov, Eugene B.; Zyubin, Andrey Yu.; Babak, Svetlana V.
• Is Part Of: Royal Society open science. Volume 4:Issue 4(2017)
• Publication Date: 2017-04-12
• Subjects: kinetic modelling -- drug metabolism -- Boolean networks; Science -- Periodicals; 500
• DOI: 10.1098/rsos.160872
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism.