Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia. (2017)

• Record Type: Journal Article
• Authors: Cuadrado, Maria M.; Ahmed, Asia; Carpenter, Ben; Brown, Jeremy S.
• Is Part Of: Respiratory medicine case reports. Volume 20(2017)
• Page Start: 184
• Page End: 187
• Publication Date: 2017
• Subjects: Organising pneumonia -- Cytomegalovirus pneumonitis -- Allogeneic stem cells transplantation (AlloHSCT); Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2017.02.005
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a marked clinical and physiological improvement after treatment with systemic corticosteroids. However, in all patients the lung function remained abnormal and in some cases imaging revealed a fibrosing lung disease. These cases represent a previously undescribed central peribronchial pattern of organising pneumonia complicating CMV pneumonitis that can result in chronic lung damage.