Heteroannulation enabled by a bimetallic Rh(iii)/Ag(i) relay catalysis: application in the total synthesis of aristolactam BII. Issue 41 (10th May 2017)

• Record Type: Journal Article
• Authors: Ji, Wei-Wei; Lin, E.; Li, Qingjiang; Wang, Honggen
• Is Part Of: Chemical communications. Volume 53:Issue 41(2017)
• Page Start: 5665
• Page End: 5668
• Publication Date: 2017-05-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02105d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Rh(iii )/Ag(i ) relay catalysis allowed the construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The synthetic application in the total synthesis was accomplished. Abstract : A redox-neutral bimetallic Rh(iii )/Ag(i ) relay catalysis allowed the efficient construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The Rh(iii ) catalyst was responsible for the C–H monofluoroalkenylation reaction, whereas the Ag(i ) salt was an activator for the follow-up cyclization. The methodology developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.